منابع مشابه
Paroxetine‐induced QTc prolongation
There have been only two previous reports of paroxetine-induced corrected QT (QTc) prolongation on electrocardiogram (ECG). Here, we report a 43-year-old woman with QTc prolongation (476 ms). She had taken 50 mg of paroxetine for 17 days. Three days after discontinuation of paroxetine, QTc returned to within the normal limits (396 ms). Paroxetine blocks the human ether-a-go-go-related gene (HER...
متن کاملKetamine-induced QTc interval prolongation
Sir, Ketamine is a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor. It is widely used as a dissociative anesthetic and is also used as an adjunct in pain management, particularly in opioid-tolerant patients. It blocks calcium channels and depresses sodium channel function as well as having anticholinergic effects. It inhibits the re-uptake of the catecholamines and may hav...
متن کاملProlongation of QTc and Risk of Stroke
Results The risk of incident stroke in study participants with prolonged QTcFram was almost 3 times the risk in those with normal QTcFram (hazard ratio [HR] [95% confidence interval (CI)]: 2.88 [2.12 to 3.92], p 0.0001). After adjustment for demographics (age, race, and sex), traditional stroke risk factors (antihypertensive medication use, systolic blood pressure, current smoking, diabetes, le...
متن کاملqtc prolongation in acute methadone poisoning
background : methadone is considered as a good choice for maintenance treatment program (mmtp) in opioid addicted individuals. qt interval prolongation was reported previously in methadone chronic usersespecially in high dose prescription. qt-interval prolongation predisposes patients to lethal dysrhythmia. this is a report of corrected qt(qtc) prolongation due to acute methadone poisoning. to ...
متن کاملPredicting QTc Prolongation in Man From Only In Vitro Data
Mishra et al.(1) in their article "Interaction between domperidone and ketoconazole: toward prediction of consequent QTc prolongation using purely in vitro information" describe the use of physiologically based pharmacokinetic (PBPK) modeling and pharmacodynamic models of cardiac repolarization to predict clinical data from preclinical data. Eliminating the risk of cardiac arrhythmias through d...
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ژورنال
عنوان ژورنال: Journal of General and Family Medicine
سال: 2017
ISSN: 2189-7948
DOI: 10.1002/jgf2.137